Prodrome Sciences Inc.

Cure

Within every prodrome is both the cause of and the cure for disease. The prodrome of a disease is the unhealthy state of a key biochemical system in your body that eventually leads to the disease. The cure is to reestablish the optimal state of the key biochemical system to both prevent disease and promote optimal health. Prodrome Sciences Inc. researches prodromes by measuring the levels of molecules in blood that indicate how biochemical systems are functioning in optimal health conditions and how they become dysfunctional prior to and during disease. The molecules we measure to diagnose disease prodromes are also the focus of our therapeutics research where our aim is not only the treatment and prevention of disease but the promotion of optimal health and longevity.

Prodrome Sciences designs therapeutics based on natural human molecules that restore dysfunctional biochemical systems to their optimal functional capacity. We develop our natural therapeutics in combination with companion diagnostic tests to precisely target individuals with a specific disease prodrome to prevent and treat disease.

Neurodegeneration Prodrome

Neuronal degeneration, the loss of function of nerve cells, is typically a slow process as we age. Everybody has a certain amount of excess brain capacity, called neuronal reserve. Neurodegeneration begins with the depletion of this neuronal reserve. As the neuronal reserve becomes depleted, the symptoms of common neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease begin to appear and then progressively get worse. In addition, the risk of stroke also increases as neuronal reserve is depleted. Other neurodegenerative diseases such as multiple sclerosis are more aggressive and occur earlier in life in persons who have the multiple sclerosis prodrome.

Dr. Goodenowe discovered that the inability to make sufficient amounts of plasmalogen molecules to maintain neuronal membrane integrity is the root of the prodrome for several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Plasmalogens are a type of lipid (fat) the body uses to keep cellular membranes in good working order. Plasmalogens are important for neurons in the brain. When membranes do not have enough of these lipid molecules, nerve cells become rigid, stop functioning properly, and eventually die.

The neurodegeneration prodrome test measures the body’s capacity to make plasmalogens. A low capacity is the prodrome to neuronal degeneration. In addition to low plasmalogens, mitochondrial impairment and an excessive pro-inflammatory environment contributes to and can accelerate neurodegeneration. The prodrome tests for multiple sclerosis and autism spectrum disorder measure these risk factors.

Plasmalogen Bioprecursors

Dr. Goodenowe’s research has shown that plasmalogen precursors can elevate, restore, and maintain healthy levels of these critical lipids. Plasmalogen precursors have been shown to prevent neurodegeneration in models of Parkinson’s disease and multiple sclerosis. Prodrome Sciences’ natural plasmalogen bioprecursors elevate, restore, and maintain healthy, protective levels of plasmalogens, despite even serious dysfunctions that may be present in the body’s plasmalogen manufacturing system. Clinical testing of Prodrome Sciences’ biotherapeutics will be performed using state-of-the-art, adaptive clinical trial designs that use Prodrome Sciences’ companion diagnostic technology to maximize trial outcomes and individual patient responses. Dr. Goodenowe’s research on the role of plasmalogens in health and neurodegeneration is available through several open-source publications such as here and here as well as in several issued and pending patent applications. Plasmalogen bioprecursors will be used to prevent and limit neurodegeneration in the following diseases. 

Neurodegeneration and dementia

Dementia is a disease that affects the brain where patients experience memory loss and difficulties with thinking. Dementia is not diagnosed using a medical laboratory test like the way cancer is diagnosed. Dementia is diagnosed using questionnaires and drawing tests that are designed to measure how certain areas of the brain are functioning. When neurodegeneration affects areas of the brain used for cognition, dementia symptoms are observed. Plasmalogen levels are decreased in the brain of persons who suffered from dementia prior to death.

Neurodegeneration and Parkinson’s disease

Parkinson’s disease is a brain and spinal cord disease where patients experience shaking and slow movement, and have difficulty walking. The stages of disease, risk factors, and symptoms are well understood. There are some treatments to manage the symptoms, but as the disease progresses treatments no longer work. When neurodegeneration affects areas of the brain used for fine motor control, movement disorder symptoms are observed. Plasmalogen levels are decreased in the brain of persons who suffered with Parkinson’s disease prior to death.

Neurodegeneration and multiple sclerosis

Multiple sclerosis (MS) is a disease of the brain and spinal cord where the insulating cells that protect nerves are damaged (a process called demyelination). This damage results in a range of symptoms including lack of coordination and impaired brain function. MS is a complicated disease that presents differently in each individual. There are some treatments for MS symptoms but there is no cure and the root cause of the disease is unknown.

Recent scientific studies show that the insulating cells (myelin) contain high levels of plasmalogen molecules. Prodrome Sciences believes during the MS disease process that causes demyelination, the body cannot make enough plasmalogen molecules to maintain the protective myelin and this is the reason plasmalogen elevating and restoring therapies can prevent demyelination.

Rhizomelic Chondrodysplasia Punctata (RCDP)

Children born with Rhizomelic Chondrodysplasia Punctata (RCDP) have rare genetic defects that prevent their body from making plasmalogen molecules. Children with RCDP have shortened limbs, intellectual disability, and breathing problems. Approximately half of the children die before their fifth birthday and nearly all of the children succumb to the disease by adolescence. There are no therapies to improve the disease and there is no cure. The severity of RCDP emphasizes how important plasmalogen molecules are to human health.

Prodrome Sciences believes that restoring the levels of plasmalogen molecules in RCDP children to the same levels in healthy children will improve their quality of life and increase their life expectancy.

 

About Prodrome Sciences Inc.

Prodrome Sciences researches prodromes of diseases – how to detect them, what causes them, and how to return high-risk prodrome states back to a healthy state before the disease develops. We use our advanced diagnostic technology for blood tests to detect disease prodromes and in our natural therapeutic programs to restore an unhealthy, high-risk prodrome state to a healthy, low-risk state. Our goal is to reduce the number of people that develop and die from disease and to promote optimal health.

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